Vaccines From Concept To Clinic

Vaccines From Concept To Clinic

Vaccine Adjuvants

Derek T. O’Hagan and a team of expert vaccinologists and pharmacologists thoroughly describe the preparation, characterization, and evaluation of a wide range of alternative vaccine adjuvants for use in preclinical studies. Each chapter carefully reviews a single adjuvant, and suggests why a specific adjuvant might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented so that researchers can choose those most efficacious for their specific purpose. Comprehensive and highly practical, Vaccine Adjuvants: Preparation Methods and Research Protocols provides an effective guide to making and using vaccine adjuvants. By closely following directions from the book, today’s researchers will be able optimally to induce specific immune responses against different types of antigens and to selectively manipulate the immune response in a favorable way.




Vaccine Adjuvants

The Retinal Muller Cell Structure and Function

The Retinal Muller Cell Structure and Function

The Leydig Cell in Health and Disease

Nearly ten years after they published the first book devoted entirely to the Leydig cell, Matthew Hardy and Anita Payne have collaborated again to provide a comprehensive study of this fascinating and important cell type. The Leydig Cell in Health and Disease presents all of the developments in our understanding of Leydig cell biology and explores a wide variety of current and potential clinical applications.





The Leydig Cell in Health and Disease

Stem Cells And Myocardial Regeneration

Stem Cells and Myocardial Regeneration is a comprehensive bench to bedside examination of stem cell-based therapies for cardiac dysfunction. The contributors, all leading researchers in their area of expertise, explore recent advances in the laboratory and in clinical trials. This volume emphasizes the near epidemic status of chronic heart failure (CHF) in the United States and abroad, and evaluates the level of success and failure of current optimal medical therapy. Specific attention is also given to both the basic cell types and pathways involved in cardiac stem cell research and the clinical issues that surround it.



Stem Cells And Myocardial Regeneration

Stem Cell Research Medical Applications and Ethical Controversy

Throughout its development in the past few years, controversy and debate have surrounded stem cell research. Since skin cells have the capability to divide, our skin can heal itself through the division of cells. Scientists have attempted to apply this theory to major organs, trying to see if stem cells can be used to make the repairs that post-mitotic cells cannot.

Stem Cell Research is a comprehensive and interesting introduction to this headline-making new science for students and nonexperts. Explaining how stems cells can be obtained from several places including skin, bone marrow, and most usefully, embryos, this book covers all the fundamental aspects of stem cell research in an easy-to-follow manner. It presents the questions surrounding the use of embryonic cells in a clear and balanced format while bringing readers up to date on the latest technological advances, applications, and issues regarding stem cell research. A bibliography, glossary, and index complete this worthwhile resource.


Stem Cell Research Medical Applications and Ethical Controversy

Renal Cell Carcinoma

Leading clinicians and researchers critically survey a decade of clinical, biological, and pathological knowledge, and show how it is best applied to the management of both localized and advanced renal cell carcinoma. Their discussions include the latest developments in molecular genetics and immune dysfunction, and fully treat the roles of partial nephrectomy, radical nephrectomy, and laparoscopy. Also discussed are screening for renal cell carcinoma, diagnosis and staging, paraneoplastic syndromes, and prognostic factors in metastatic disease. The physicians further explore novel therapeutic aspects including the use of interferon, Interleukin-2, therapy for metastatic renal cell carcinoma, monoclonal antibody therapies, and antiangiogenic treatments to name a few. Summarizing a decade of scientific and therapeutic innovation, Renal Cell Carcinoma offers all physicians and clinical investigators treating kidney cancer today’s gold-standard compendium of practical knowledge about the nature, diagnosis, and treatment of this difficult disease.




Renal Cell Carcinoma

Planar Cell Polarization during Development

Description
Cellular polarization is key to all cellular functions. Our perceptions, which are derived from our senses, depend on the proper cellular polarization of our sense organs, such as the eyes or ears. Much of this book examines the different aspects in cellular polarization and its researched role in the Drosophila, where the first planar cellular polarity (PCP) gene was discovered over 20 years ago. Topics also include: From flies to man: how we are polarized, Marking an embryo work, Cellular polarization at its functional best, Hearing and seeing your environment, and From a cell to an organ. This series represents timely issues in developmental biology. It provides annual reviews of selected topics, written from the perspectives of leading investigators in the field of development.

Audience
Developmental Biologists, Cell Biologists, Entomologists, Geneticists, Libraries of Acamdemic Institutions, Medican Institutions

Contents
Planar Polarity in the Drosophila Wing Planar Cell Polarity in the Drosophila Eye: Cell Fate and Organization Long-range Coordination of planar polarity patterning in Drosophila Dorsoventral boundary for organizing growth and planar polarity in the Drosophila eye Recent discoveries in vertebrate non-canonical Wnt signaling: Toward a Wnt signaling network Planar cell polarity in the vertebrate inner ear Morphogenetic cell movements shaping the zebrafish gastrula

Planar Cell Polarization during Development

New Developments and New Applications in Animal Cell Technology

Animal cell technology is becoming an increasingly important part of biotechnology and many products are now used in human health care and for veterinary applications. However, there are many times more products actually in the developmental pipelines of the biotechnology industry, including various phases of clinical trials. The Proceedings of the 15th Meeting of the European Society for Animal Cell Technology (Tours, France, September 1997) presents the actual current state as well as New Developments and Applications in Animal Cell Technology for the benefit of society.
These Proceedings represent both the current state and applications of animal cell technology and the way the technology is expanding into new areas to give a unique insight into new products and applications for human and animal health care.


New Developments and New Applications in Animal Cell Technology

MICELLAR CATALYSIS

Features
Provides detailed mechanisms for all types of micelle-mediated reactions
Explains how physicochemical properties and intermolecular interactions of micelles influence reaction mechanisms
Includes dispersed medium (DM) model of micellar solution
Analyzes how micelles affect reaction rates and rate constants in unimolecular, solvolytic, and bimolecular organic reactions
Covers the effects of mixed aqueous-organic solvents on the micellar binding constants of solubilizates
Illustrates how industrial processes can benefit from micellar-mediated chemical reactions

Summary
Micelles are prevalent in naturally occurring and biological catalytic reactions. However, it is only in recent decades that scientists have developed kinetic models clarifying how micelle-mediated catalysis works at a molecular level. Written by a leading expert in the field, Micellar Catalysis is an in-depth examination of how micelles affect reaction mechanisms and reaction rates in organic and inorganic reactions.

The book first discusses the structural and chemical properties of micelles and the role of thermodynamics, concentration, and additives in forming micelles. Demonstrating how intermolecular forces influence the reaction mechanisms, the author presents kinetic models for reactions catalyzed by normal micelles, as well as mixed micelles and metallomicelles. The book also compares various types of catalytic reactions with and without micelles to quantify their effect on reaction rates and rate constants. Using this information, it illustrates how micelles can modify reaction rates and improve catalytic efficiency, particularly for industrial processes. The final chapter explains the principles of kinetics used for data analysis.

Focused on kinetic, chemical, and physical aspects of micelle-mediated reactions, this book offers clear insight into the complex mechanisms that occur in biological reactions. Micellar Catalysis is an essential source of reference for scientists involved in the research and development of micelles for industrial and biochemical applications.



MICELLAR CATALYSIS

Human Cell Culture Primary Mesenchymal Cells

This unique comprehensive volume in the Human Cell Culture Series encompasses research methodology for the growth and differentiation of all types of primary mesenchymal cells. Each of eleven mesenchymal cell types is covered by a leading expert in the field, providing insightful background information along with detailed current culture and assay techniques. Tissue types covered include bone, cartilage, tendons and ligaments, muscle (smooth, skeletal, and cardiac), adipose tissue, and skin (dermis), as well as multi-potent mesenchymal stem cells and fibrocytes. In addition to uses for research applications, current and future clinical applications of large-scale culture methods are also discussed. Further, the procurement and processing of primary human tissues is covered in detail. The generous inclusion of figures and tables, along with a consistent format, makes critical information highly accessible to the reader. Additionally, numerous literature citations provide a valuable reference for students and professionals in the fields of cell biology and bioengineering.




Human Cell Culture Primary Mesenchymal Cells

Cell Therapy Stem Cells and Brain Repair

Cell Therapy, Stem Cells, and Brain Repair reviews the most compelling treatments for neurodegenerative diseases, disorders, and injuries, including Parkinson's disease, Huntington's disease, traumatic brain injury, and stroke. Covering the history of cell therapy and neural transplantation, it also focuses on stem cells, including embryonic, bone marrow, and umbilical cord blood, as well as other investigative sources. This compilation explicates previous cornerstones and milestones of neurological cellular therapy, which have provided a foundation for modern stem cell research.
In Cell Therapy, Stem Cells, and Brain Repair, the challenges and current direction of cellular research are described in great detail. Modern techniques involving certain subsets of cell populations are also explained. In addition, the ongoing discovery of stem cell sources for cell therapy is discussed, while expounding upon clinical applications for cellular therapeutic brain repair as certain cells become increasingly promising.
Explaining the field of cell therapy from a scientific, clinical, and ethical perspective, Cell Therapy, Stem Cell, and Brain Repair is essential reading for neurologists, scientists, and clinicians looking to stay on the cutting-edge of regenerative medicine.





Cell Therapy Stem Cells and Brain Repair

Cell Surface Proteases

Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource.

* Provides an overview of the entire field of cell surface proteases in a single volume
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage





Cell Surface Proteases

Cell Separation

Advances in BiochemicalEngineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, micro-biology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 35 years. It also discusses new discoveries and applications. Special volumes are edited by well known guest editors who invite reputed authors for there view articles in their volumes.




Cell Separation

Cell Death The Role of PARP

Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.



Cell Death The Role of PARP

Artificial Cells

This is the first book that provides a comprehensive review of the entire area of artificial cells. The author, a pioneer of the field, invented the first artificial cells some 50 years ago and has continued to carry out active research in this field. Since then, there have been explosive research activities around the world on artificial cells, especially in fields related to biotechnology, nanomedicine, cell therapy, blood substitutes, drug delivery and others. However, instead of the term artificial cells, many authors use other terminologies such blood substitutes, bioencapsulation, liposomes, nanoparticles, and so on. As a result, any meaningful literature search for a complete idea of the present status of the whole field of artificial cells is impossible. Furthermore, the fact that papers in this highly interdisciplinary area are published in numerous journals specializing in chemistry, medicine, surgery, bioengineering, and others, makes literature search even more difficult. Books in this area are mostly multi-authored, describing very specific and narrow areas. Therefore, many who enter this field for the first time cannot find any book that describes laboratory methods and procedures needed for starting their research. This monograph is written to fill this gap. Based on his 50 years of work and an interdisciplinary background, the author has managed to include all those areas in artificial cells that are disguised under different terminologies. Since this is a very large area, he starts each chapter by giving a detailed overview and has included more than 1000 references to facilitate easier literature search of this highly interdisciplinary area. Detailed examples of the author s own research are given and methods and procedures are described in detail. Readers interested in a detailed overview of the whole area can read from cover to cover but omitting the methods section at the end of each chapter. On the other hand, those entering this area of research will find the detailed methods and procedures very useful.




Artificial Cells

Antigen-Presenting Cells and the Eye

In recent years the importance of antigen-presenting cells and their influence on the eyes has been elucidated. We have learned that nearly every structure of the eye harbors these cells, yet they differ in their activities and thus in the ways in which they protect against - or participate in - diseases of the eye. Antigen-Presenting Cells and the Eye summarizes current knowledge about ACPs in general, and their role in the eye, in particular.


Antigen-Presenting Cells and the Eye

Understanding Breast Cancer Genetics

This is a wonderfully well written book in concise form for easy reading.The content is as up to date, as anyone can wish, containing all the latest information on the genetics of breast cancer not easily found in other publications.I have already found it extremely useful and have referred to it in lectures to doctors and medical students.


Understanding Breast Cancer Genetics

Pancreatic Cancer

Description: Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. We have seen the development of the first mouse models that accurately recapitulate features of the human disease. Several landmark clinical trials in both resectable and metastatic pancreatic cancer have been completed, raising new questions about the standard of care in this disease. Finally, the era of targeted biologic therapies has engendered new excitement about the prospects of more rapid progress in understanding and successfully treating this dreadful disease. Therefore, it is an appropriate time to review these important advances and outline areas of controversy and question in pancreatic cancer biology and treatment.




Pancreatic Cancer

Molecular Pathology of Gynecologic Cancer

Molecular Pathology of Gynecologic Cancer focuses on putting successful molecular strategies into practice for the treatment of gynecologic cancer. The volume begins with an explication of the editors’ hypothesis that cancer is mainly a disease of the cell cycle, based on the deregulation of the physiological process of cell reproduction. The following eleven chapters focus on specific issues in gynecologic cancers, including: a proposed model of ovarian serous carcinogenesis, molecular markers for ovarian epithelial cancer, an overview of the pathology of endometrial cancer, molecular genetic aspects of endometrial carcinoma and cervical cancer, a natural history of Human Papilloma Virus (HPV) as it relates to cervical cancer, and hereditary issues in gynecologic cancers. The concluding chapter proposes and outlines a holistic approach to the treatment of female cancer patients. This new volume in Humana’s Current Clinical Oncology™ series will be necessary reading for clinicians and experimental researchers alike.



Molecular Pathology of Gynecologic Cancer

Handbook of Cancer Survivorship

Description: The Handbook on Cancer Survivorship responds to the diverse needs of survivors and their support communities by comprehensively addressing the major issues in the field, from the burden of survivorship to secondary prevention. Editor Michael Feuerstein, himself a cancer survivor, and sixty other top scientist-practitioners analyze in depth how survivors meet and manage the challenges of life after cancer, and what clinicians, researchers, and public health systems can do to ease the transition.



Handbook of Cancer Survivorship

Gene Therapy of Cancer Second Edition

The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer.

Key Features
* Provides in-depth description of targeted systems and treatment strategies
* Explains the underlying cancer biology necessary for understanding a given therapeutic approach
* Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses
* Presents translational focus with emphasis on requirements for clinical implementation
* Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference



Gene Therapy of Cancer Second Edition

Fluoropyrimidine in Cancer Therapy

Leading cancer researchers update and review the mechanisms of action and the therapeutic selectivity and efficacy of 5-FU with and without leucovorin and its prodrugs in the treatment of colorectal cancer. Among the combination agents considered are UFT/LV, 5-FU/EU, capecitabine (Xeloda), S-1, and a variety of thymidylate synthase inhibitors. The authors discuss the potential advantages and disadvantages of these varied drugs and their mode of administration. Based on historical results with these agents when used alone, they also present a rationale for their results when used in combination with other agents.


Fluoropyrimidine in Cancer Therapy

Complementary Oncology Adjunctive Methods in the Treatment of Cancer

Complementary Oncology is an excellent and open minded exploration of treatment options from a conventional medicine point of view. Even though this book is written by German doctors and researchers engaged in providing conventional care, the discussion is primarily on complementary treatment options and exhibits little or no bias.

Research and potential of many aspects such as exercise, nutrition, psychology, thermography, and many other treatments is well presented (although a bit scientific at times).

Care like proteolytic enzymes apparently is so common in Germany that it isn't even discussed, it's just assumed the patient will include them in their care (they are listed in the back as part of each care plan).

This book isn't for the average cancer patient. However if you have a scientific education and an interest in solid research of topics typically not mentioned or considered by American doctors then this is an excellent book to read. If you are a patient interested in obtaining the best care without bias or a caregiver that desires to be well educated then this book should be a "must have".



Complementary Oncology Adjunctive Methods in the Treatment of Cancer

Chemoradiation in Cancer Therapy

Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy.

Chemoradiation in Cancer Therapy (Cancer Drug Discovery and Development)
By

* Publisher: Humana Press
* Number Of Pages: 432
* Publication Date: 2002-12-04
* Sales Rank: 2410289
* ISBN / ASIN: 158829028X
* EAN: 9781588290281
* Binding: Hardcover
* Manufacturer: Humana Press
* Studio: Humana Press
* Average Rating:
* Total Reviews:

Book Description:

Internationally recognized experts in cancer biology and clinical research review the present status of the multimodality approach to the management of solid tumors and speculate on possible future strategies for chemoradiation therapy. The authors detail applications of combined modality therapy in lung, esophageal, breast, gastric, pancreatic, colon, and rectal cancers. They also show how radiation interacts with such chemotherapeutic agents as the platinum complexes, taxanes, and gemcitabine in the treatment of malignant gliomas, and head and neck cancer. A review of how to integrate new specific molecular targeted agents into multimodality therapy in the future.



Chemoradiation in Cancer Therapy

Cancer Drug Resistance

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.


Cancer Drug Resistance

Breast Cancer Genes and the Gendering of Knowledge

The book examines the social and cultural context of new genetic knowledge associated with breast cancer. It looks at how this knowledge and technologies are used and received in two contrasting social arenas--cancer genetic clinics and a breast cancer research charity.


Breast Cancer Genes and the Gendering of Knowledge

Asbestos Selected Cancers 1,2

In conjunction with drafting comprehensive legislation concerning compensation for health effects related to asbestos exposure (the Fairness in Asbestos Injury Act), the Senate Committee on the Judiciary directed the Institute of Medicine to assemble the Committee on Asbestos: Selected Health Effects. This committee was charged with addressing whether asbestos exposure is causally related to adverse health consequences in addition to asbestosis, mesothelioma, and lung cancer. Asbestos: Selected Cancers presents the committee's comprehensive distillation of the peer-reviewed scientific and medical literature regarding association between asbestos and colorectal, laryngeal, esophageal, pharyngeal, and stomach cancers.


Asbestos Selected Cancers 1

Asbestos Selected Cancers 2

Apoptosis Senescence and Cancer

Apoptosis, Senescence and Cancer provides insight into established practices and research into apoptosis and senescence by thoroughly examining novel and emerging techniques and research in the fields of cell death pathways, senescence growth arrest, drugs and resistance, DNA damage response, and other topics which still hold mysteries for researchers.

The volume is divided into six easy to follow sections. The first is Apoptosis and Alternative Modes of Cell Death, followed by chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The third part covers DNA Damage Response, Signaling Pathways and Tumorigenesis, while the fourth delves into Resistance and Sensitization. The book concludes with Established Cancer Therapies and a section which looks toward the future with Recent and Developing Cancer Therapies.

In total, this volume provides basic scientists and clinicians with a deeper and more complete understanding of the cellular responses of malignancies which may determine the effectiveness of treatment, both in the initial stages of the disease as well as in disease recurrence.



Apoptosis Senescence and Cancer

Antiangiogenic Agents in Cancer Therapy

Beverly Teicher and a panel of distinguished investigators survey the state-of-the-art of antiangiogenesis research from the lab bench to clinical trials. Timely and authoritative, the contributors summarize our current understanding of tumor growth and its dependence on vascular development, as well as the present status of antiangiogenic agents in preclinical and clinical development. In addition, the book also examines what is known about the mechanisms by which these therapeutic agents interfere with tumor vasculature and grapples with the problem of establishing criteria by which to assess their clinical efficacy. Antiangiogenic Agents in Cancer Therapy offers a unique cutting-edge compendium of antiangiogenic research, taking stock of what has been accomplished , where the experimental therapeutics of antiangiogenic agents is going, and the continuing evolution of their role in cancer treatment and novel drug development.


Antiangiogenic Agents in Cancer Therapy

Alison The Cancer Handbook

Providing a comprehensive overview of scientific and clinical information in all major areas of cancer biology and medicine, The Cancer Handbook stands out from existing oncology textbooks and reference works in that it bridges the gap between the molecular biology of cancer and clinical diagnosis and treatment.

Covering a wide range of subjects - from basic cell biology to the systemic oncology of all major organs and tissues - the content of The Cancer Handbook has been organised into six major sections:

The Molecular Basis of Cell and Tissue Organisation
The Causation and Prevention of Cancer
Diagnostic Imaging and Image-Guided Intervention
Systemic Oncology
Pre-Clinical Models for Human Cancer
The Treatment of Human Cancer

It is an indispensable resource for medical and life science students, and all scientists, clinicians and researchers working in the cancer field and related biomedical areas.


Alison The Cancer Handbook

Advances in Radiation Oncology in Lung Cancer

Although decades of laboratory and clinical research have led to incremental improvement in treatment outcome, lung cancer remains one of the most deadly diseases. This volume is unique in being devoted solely to the radiation oncology of lung cancer, and will be of great value to all who are involved in the diagnosis and treatment of the disease. Both non-small cell and small cell lung cancer are considered in detail. Current state-of-the-art treatment strategies and novel approaches that promise further improvements in outcome are explained and evaluated, with the aid of high-quality illustrations. Treatment-related toxicity is discussed, and further individual chapters focus on topics such as quality of life studies, prognostic factors and pitfalls in the design and analysis of clinical trials.
If you look at the map of the world and check the incidence rates of cancer, you will find lung cancer as one of the major health problems worldwide. This is irrespective of sex and age, health care systems and current media reports. It is simply a fact that we sometimes forget, but it always comes again as a reminder with every new patient worldwide. This burden is present for decades and although there seems to be stagnation in males, plateau is not reached in females yet. Even then, we would still have to deal with thousands of patients suffering from the deadly disease. And we deal with it with radiation therapy, a treatment modality being now older than one-hundred years. During that period we have learnt how to fractionate the dose and observe the effects both on tumors and normal tissues. We have also learnt how to combine radiation therapy with other treatment modalities. With the time, we became increasingly capable of documenting dose distribution and to build on computerised-driven technologies to image, verify and record. We also became capable of concentrating on progressively smaller and smaller constituents; from the whole body to organs and tissues and from them to cells and molecules. We use radiation biology and molecular oncology to provide necessary framework for the science of radiation oncology in lung cancer.
And this book is about it; what had been done and what is going on. But much more than that, it is a book of what we have learnt from the past and how successfully we should incorporate it in our future endeavours, all having the same aim, better radiation oncology of lung cancer patients.


Advances in Radiation Oncology in Lung Cancer

Vitamin E

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

Vitamin E

Vitamin Analysis for the Health and Food Sciences

Employing a uniform, easy-to-use format, Vitamin Analysis for the Health and Food Sciences, Second Edition provides the most current information on the methods of vitamin analysis applicable to foods, supplements, and pharmaceuticals. Highlighting the rapid advancement of vitamin assay methodology, this edition emphasizes the use of improved and sophisticated instrumentation including the recent applications and impact of the widely adopted LC-MS. Designed as a bench reference, this volume gives you the tools to make efficient and correct decisions regarding the appropriate analytical approach--saving time and effort in the lab.


Vitamin Analysis for the Health and Food Sciences

Unhealthy Places The Ecology of Risk in the Urban Landscape

Unhealthy Places focuses on issues of health in today's cities. By arguing that "place matters" in relation to the population's health, Kevin Fitzpatrick and Mark LaGory make a convincing argument about the general unhealthiness of urban environments and, thus, of the urban dweller. The authors offer a place-oriented approach to health and cover such topics as the ecology of everyday urban life, the sociology of health, needs and risks of the socially disadvantaged, needs and risks of children and the elderly in cities, and strategies for better health services in urban environments.



Unhealthy Places The Ecology of Risk in the Urban Landscape

Type 1 Diabetes in Clinical Practice

A concise survey by physicians and researchers of the latest thinking about the causes of diabetes and the best approaches to treating its acute and chronic complications. The authors pay special attention to explaining the molecular basis of diabetes and its complications, as well as to the many recent developments in whole pancreas and islet cell transplantation, including the means for avoiding the rejection of transplanted islets.



Type 1 Diabetes in Clinical Practice

Treatment of the Obese Patient

Treatment of the Obese Patient is a timely and informative text for all health care providers challenged with helping patients manage weight. This volume includes insight into recent scientific advances in obesity research and provides the most up-to-date reviews of current treatment issues and strategies.

The volume is divided into two parts. Part I covers new discoveries in the physiological control of body weight, as well as the pathophysiology of obesity. Expert authors discuss pathways that control food intake, energy expenditure, and peripheral nutrient metabolism, including a look at the emerging evidence of the role of adipose tissue as an endocrine organ. Part 2 covers issues central to clinical management. Authors in this section discuss polycystic ovarian syndrome, diabetes, energy density, glycemic index, low-carbohydrate diets, the role of physical activity, and novel approaches to pharmacotherapy, surgery, and management of micronutrient deficiencies in the postbariatric patient. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient is an essential volume for clinical endocrinologists and other health care providers.



Treatment of the Obese Patient

Treatment Planning for Traumatized Teeth

Increased knowledge of treatment outcomes, combined with better techniques and materials, has led to improved managemetn and more predictable results for victims of dental trauma. To save teeth and restore function and esthetics, the clinical approach to dental trauma requires accurate diagnosis of the severity and extent of injury, treatment of the acute aspect of the injury, and long-term follow-up and treatment of injury sequelae. Each chapter is arranged by: description; examination and diagnosis; key points; treatment plan; and treatment procedures. Described is the biologic basis of healing and the benefits of allowing healing to be used in the management of traumatic dental injuries. Also described are the roles orthodontic and restorative modalities play in the management of dental trauma.
More than 50 cases and 480 exceptional images��intraoral, radiographic, and schematic��elucidate the most effective approaches to all forms of dental trauma.


Treatment Planning for Traumatized Teeth

Transgenics in Endocrinology

A panel of expert clinical and basic investigators summarize the state-of-the-art in the use of transgenic technology in a broad range of endocrinological applications. Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology and its pathologies through mouse models, and provides a host of creative approaches to understand better the complex processes that are characteristic of hormonal systems.


Transgenics in Endocrinology

Transactions in Condensation Polymers

Transactions in Condensation Polymers

Tracheostomy A Multi-professional Handbook

Tracheostomy: A Multi-Professional Handbook is written by a multidisciplinary team of authors to give a unique perspective of this increasingly widely-used technique and which will support research-based care and management and deliver patient-focused rehabilitation. It covers everything from the basics of tracheostomy, through the indications for tracheostomy and all aspects of pre-, peri- and postoperative care of the patient. The latter forms a large part of the book, and focuses on issues of importance to a broad spectrum of healthcare professionals, such as how patient communication is affected by the technique and how optimum wound care during tracheostomy is best achieved, as well as the practical aspects and problems encountered with speech, swallowing and general rehabilitation, nutrition, weaning and decannulation, long-term tracheostomy, tracheostomy in children, and an important chapter on emergency tracheostomy techniques.



Tracheostomy A Multi-professional Handbook

Tissue Engineering

Increasingly viewed as the future of medicine, the field of tissue engineering is still in its infancy. As evidenced in both the scientific and popular press, there exists considerable excitement surrounding the strategy of regenerative medicine. To achieve its highest potential, a series of technological advances must be made. Putting the numerous breakthroughs made in this field into a broad context, Tissue Engineering disseminates current thinking on the development of engineered tissues. Divided into three sections, the book covers the fundamentals of tissue engineering, enabling technologies, and tissue engineering applications. It examines the properties of stem cells, primary cells, growth factors, and extracellular matrix as well as their impact on the development of tissue engineered devices. Contributions focus on those strategies typically incorporated into tissue engineered devices or utilized in their development, including scaffolds, nanocomposites, bioreactors, drug delivery systems, and gene therapy techniques. Finally, the book presents synthetic tissues and organs that are currently under development for regenerative medicine applications. The ability to engineer biocompatible tissue is the hallmark of modern biomedical engineering, integrating all aspects of every sub-discipline in the field. Featuring chapters drawn from the third edition of the best-selling Handbook of Biomedical Engineering as well as new contributions not found in the handbook, Tissue Engineering surveys the latest advances in this relatively young area. The contributing authors are a diverse group with backgrounds in academia, clinical medicine, and industry. Furthermore, the text includes contributions from Europe, Asia, and North America, helping to broaden the views on the development and application of tissue engineered devices.



Tissue Engineering

Thrombolytic Therapy for Stroke

The world's leading experts detail the basic rationale, scientific evidence, and treatment protocol for thrombolytic therapy in acute stroke patients. These experienced clinicians show how promptly delivered thrombolysis can restore cerebral blood flow in time to salvage brain and neurologic functions, first by reviewing the preclinical development of thrombolytics, and then by presenting the pivotal clinical trials that proved their efficacy and safety. Their description of the treatment protocol discusses field triage and management, emergency department therapy, brain imaging, clinical decision making and patient selection, drug administration, post-thrombolysis management, and the treatment of complications. Comprehensive and highly practical, Thrombolytic Therapy for Stroke offers the practicing physician everything necessary-background, protocols, and case studies-for the safe and effective treatment of the emergency stroke patient today.


Thrombolytic Therapy for Stroke

The Zebrafish Genetics Genomics and Informatics

This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community.

* Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls
* Illustrates many techiques in full-color
* Summarizes the Zebrafish Genome Project


The Zebrafish Genetics Genomics and Informatics

THE PSYCHOLOGY OF LEARNING AND MOTIVATION

The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.




THE PSYCHOLOGY OF LEARNING AND MOTIVATION

The Genetics of Male Fertility

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.

This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.

Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.




The Genetics of Male Fertility

The Influence of Genetics on Contemporary Thinking

This volume reflects on the effects of recent discoveries in genetics on a broad range of scientific fields. In addition to neuroscience, evolutionary biology, anthropology and medicine, contributors analyze the effects of genetics on theories of health, law, epistemology and philosophy of biology. Social and moral concerns about the relationship between genetics, society and the individual also figure prominently. Genetic discoveries fuel central contemporary public policy debates concerning, for example, human cloning, equitable access to healthcare or the role of genetics in medicine. Perhaps more fundamentally, advances in genetics are altering our perception of human life and death.
An interview with FranAois Jacob by Anne Fagot-Largeault opens the volume. In this interview, Jacob, who shared a Nobel Prize with AndrA(c) Lwoff and Jacques Monod for their discoveries concerning genetic control of enzyme and virus synthesis, addresses many of the central methodological epistemological and ethical questions covered in the volume. The dynamic interdisciplinary character of this volume makes it relevant to scholars from many disciplines, from biology, philosophy and the social sciences.



The Influence of Genetics on Contemporary Thinking

Structural Shielding Design for Medical X-Ray Imaging Facilities

Report No. 147 (2004) presents recommendations and technical information related to the design and installation of structural shielding for facilities that use x rays for medical imaging. The purpose of structural shielding is to limit radiation exposure to employees and members of the public. The information supersedes the recommendations that address such facilities in NCRP Report No. 49, Structural Shielding Design and Evaluation for Medical Use of X Rays and Gamma Rays of Energies Up to 10 MeV, which was issued in September 1976. NCRP Report No. 147 includes a discussion of the various factors to be considered in the selection of appropriate shielding materials and in the calculation of barrier thicknesses. The Report presents the fundamentals of radiation shielding, discusses shielding design goals for controlled and uncontrolled areas in or near x-ray imaging facilities and defines the relationship of these goals to the NCRP effective dose limits for radiation workers and members of the public. The Report includes a detailed discussion of the recommended shielding design methodology for x-ray imaging facilities and provides an extensive collection of shielding data and sample shielding calculations for various types of x-ray imaging facilities. The Report is mainly intended for those individuals who specialize in radiation protection. However, it will also be of interest to architects, hospital administrators and related professionals concerned with the planning of new facilities that use x rays for medical imaging. View the latest Book Review of this Report.



Structural Shielding Design for Medical X-Ray Imaging Facilities

Smart Textiles For Medicine And Healthcare

- unlocks the significant potential of smart textiles within the healthcare industry
- provides a unique insight into recent developments in this exciting field
Smart or intelligent textiles are a relatively novel area of research within the textile industry with enormous potential within the healthcare industry. This book provides a unique insight into recent developments in how smart textiles are being used in the medical field.
The first part of the book assesses trends in smart medical textiles. Chapters cover topics such as wound care materials, drug-based release systems and electronic sensors for health care. The second part of the book discusses the role of smart textile in monitoring the health of particular groups such as pregnant women, children, the elderly and those with particular physical disabilities.
With its distinguished editor and team of international contributors, this book provides a unique and essential reference to those concerned with intelligent textiles in healthcare.


Smart Textiles For Medicine And Healthcare

Sexual Health and Genital Medicine in Clinical Practice

This book covers the range of conditions seen in sexually transmitted infection clinics and genito-urinary clinics making it a useful and practical guide to all health practitioners in this area.

However, as genital infections and medical problems are very similar worldwide, any practitioner
managing genital disease and sexual health problems should find this book of practical value.

The book is aimed specifically at medical practitioners in primary care who require a quick guide to help diagnose and manage genital problems - a prompt to ‘what to do next’ when faced with a patient with a genital complaint. The book has many colour illustrations, with key points and summary boxes helping to make the book a quick reference guide.





Sexual Health and Genital Medicine in Clinical Practice